4RLO

Human p70s6k1 with ruthenium-based inhibitor EM5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ribosomal protein S6 kinase beta-1	polymer	288	32691.3	2	UniProt (P23443) Pfam (PF00069)	Homo sapiens (human)	S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA
2	C (A)	[(amino-kappaN)methanethiolato](3-fluoro-9-hydroxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium	non-polymer		662.8	1	Chemie (3T3)
3	D, J, K (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL) PubChem (753)
4	E, F, G, L, M... (A, B)	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL) PubChem (312)
5	H, O (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	I (B)	STAUROSPORINE	non-polymer		466.5	1	Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898)
7	P (B)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS) PubChem (679)
8	Q, R (A, B)	water	water		18.0	82	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65382.7
Non-Polymers*	Number of molecules	14
	Total formula weight	1888.6
All*	Total formula weight	67271.2

*Water molecules are not included.