4RL2
Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase NDM-1 | polymer | 246 | 26045.3 | 2 | UniProt (C7C422) Pfam (PF00753) | Klebsiella pneumoniae | NDM-1, Metallo-beta-lactamase NDM-1 |
| 2 | C, D, F, G (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, H (A, B) | (1R)-2-({(R)-carboxy[(2R,5S)-4-carboxy-5-methyl-5,6-dihydro-2H-1,3-thiazin-2-yl]methyl}amino)-2-oxo-1-phenylethanaminium | non-polymer | 366.4 | 2 | Chemie (3S3) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 438 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 270 (UniProt: C7C422)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ser 26 | - | expression tag |
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52090.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 994.5 | |
| All* | Total formula weight | 53085.0 |
