4RKO
Crystal structure of thrombin mutant S195T bound with PPACK
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Thrombin heavy chain | polymer | 259 | 29794.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | B (A) | Thrombin light chain | polymer | 42 | 4860.4 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 3 | C (B) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 4 | D (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | E, F (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | G (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | H (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | I, J (B, A) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
B: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Thr 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34654.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1077.6 | |
| All* | Total formula weight | 35732.3 |
