4RJ8
EGFR kinase (T790M/L858R) with inhibitor compound 8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 331 | 37549.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine | non-polymer | 392.5 | 1 | Chemie (3QS) | |||
| 4 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
| Ala 865 | Glu 865 | engineered mutation |
| Ala 866 | Glu 866 | engineered mutation |
| Ala 867 | Lys 867 | engineered mutation |
| Asn 1023 | - | expression tag |
| Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37549.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 488.6 | |
| All* | Total formula weight | 38038.0 |
