4RIX
Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Receptor tyrosine-protein kinase erbB-3 | polymer | 326 | 36519.2 | 2 | UniProt (P21860) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3 |
| 2 | B, D (B, D) | Epidermal growth factor receptor | polymer | 345 | 39167.2 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 3 | E, I (A, C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | F, H, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | G, K (B, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A, C: 679 - 1001 (UniProt: P21860)
B, D: 658 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 676 | - | expression tag |
| Ala 677 | - | expression tag |
| Gly 678 | - | expression tag |
| Arg 790 | Gln 809 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 654 | - | expression tag |
| Ala 655 | - | expression tag |
| Met 656 | - | expression tag |
| Gly 657 | - | expression tag |
| Arg 924 | Val 948 | engineered mutation |
| Ala 973 | Phe 997 | engineered mutation |
| Ala 977 | Leu 1001 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 151372.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1964.0 | |
| All* | Total formula weight | 153336.9 |
