4RIX

Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Receptor tyrosine-protein kinase erbB-3	polymer	326	36519.2	2	UniProt (P21860) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3
2	B, D	Epidermal growth factor receptor	polymer	345	39167.2	2	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
3	A, C	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	B, D	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)

Sequence modifications

A, C: 679 - 1001 (UniProt: P21860)

PDB	External Database	Details
Gly 676	-	expression tag
Ala 677	-	expression tag
Gly 678	-	expression tag
Arg 790	Gln 809	engineered mutation

B, D: 658 - 998 (UniProt: P00533)

PDB	External Database	Details
Gly 654	-	expression tag
Ala 655	-	expression tag
Met 656	-	expression tag
Gly 657	-	expression tag
Arg 924	Val 948	engineered mutation
Ala 973	Phe 997	engineered mutation
Ala 977	Leu 1001	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	151372.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1964.0
All*	Total formula weight	153336.9

*Water molecules are not included.