4RIO
Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK3 | polymer | 293 | 33254.0 | 1 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| 2 | B (A) | 4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide | non-polymer | 276.3 | 1 | Chemie (3QX) | |||
| 3 | C (A) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 810 - 1100 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Gly 808 | - | expression tag |
| Pro 809 | - | expression tag |
| Ser 811 | Cys 811 | engineered mutation |
| Ser 1040 | Cys 1040 | engineered mutation |
| Ser 1048 | Cys 1048 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33254.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 33530.3 |
