4RI4

Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein phosphatase non-receptor type 3	polymer	306	34897.7	2	UniProt (P26045) Pfam (PF00102) In PDB	Homo sapiens (human)
2	A, B	VANADATE ION	non-polymer		114.9	2	Chemie (VO4)
3		water	water		18.0	535	Chemie (HOH)

Sequence modifications

A, B: 628 - 909 (UniProt: P26045)

PDB	External Database	Details
Met -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Ile 676	Tyr 676	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69795.4
Non-Polymers*	Number of molecules	2
	Total formula weight	229.9
All*	Total formula weight	70025.3

*Water molecules are not included.