4RHG
Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 3 | polymer | 306 | 34945.7 | 1 | UniProt (P26045) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase H1, PTP-H1 |
2 | B | Epidermal growth factor receptor substrate 15 | polymer | 9 | 1124.0 | 1 | UniProt (P42566) In PDB | Homo sapiens | Protein Eps15, Protein AF-1p |
3 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 628 - 909 (UniProt: P26045)
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Leu -11 | - | expression tag |
Gly -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
Glu 811 | Asp 811 | engineered mutation |
Ser 842 | Cys 842 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 36069.7 | |
All* | Total formula weight | 36069.7 |