4RH9

Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 3	polymer	306	34822.5	1	UniProt (P26045) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase H1, PTP-H1
2	B (B)	Epidermal growth factor receptor substrate 15	polymer	9	1124.0	1	UniProt (P42566)	Homo sapiens	Protein Eps15, Protein AF-1p
3	C, D (A, B)	water	water		18.0	196	Chemie (HOH)

Sequence modifications

A: 628 - 909 (UniProt: P26045)

PDB	External Database	Details
Met -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Ala 811	Asp 811	engineered mutation
Phe 812	His 812	engineered mutation
Ser 842	Cys 842	engineered mutation
Gly 883	Met 883	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35946.6
All*	Total formula weight	35946.6

*Water molecules are not included.