4RED

Crystal structure of human AMPK alpha1 KD-AID with K43A mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	5'-AMP-activated protein kinase catalytic subunit alpha-1	polymer	351	40200.2	2	UniProt (Q13131) Pfam (PF00069) Pfam (PF21147) In PDB	Homo sapiens (human)	AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1
2		water	water		18.0	30	Chemie (HOH)

Sequence modifications

A, B: 13 - 353 (UniProt: Q13131)

PDB	External Database	Details
Met 3	-	expression tag
Gly 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
Ala 43	Lys 52	engineered mutation
Ser 260	Thr 269	conflict
Thr 287	Ser 296	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80400.5
All*	Total formula weight	80400.5

*Water molecules are not included.