4RAO
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 217 | 24481.2 | 4 | UniProt (P00492) Pfam (PF00156) In PDB | Homo sapiens (human) | HGPRT, HGPRTase |
| 2 | A, B, C, D | (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid | non-polymer | 437.3 | 4 | Chemie (3L7) | |||
| 3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97924.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1943.6 | |
| All* | Total formula weight | 99868.4 |
