4RAD
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 217 | 24481.2 | 8 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT, HGPRTase |
| 2 | I, K, N, P, R... (A, B, C, D, E...) | (2-{[2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl][2-(2-phosphonoethoxy)ethyl]amino}ethyl)phosphonic acid | non-polymer | 454.3 | 8 | Chemie (3L5) | |||
| 3 | J, L, M, O, Q... (A, B, C, D, F...) | MAGNESIUM ION | non-polymer | 24.3 | 9 | Chemie (MG) | |||
| 4 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 598 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 195849.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3853.2 | |
| All* | Total formula weight | 199703.0 |
