4RAC
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 217 | 24481.2 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT, HGPRTase |
| 2 | E, H, K, N (A, B, C, D) | [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid | non-polymer | 438.3 | 4 | Chemie (3L4) | |||
| 3 | F, G, I, J, L... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 4 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97924.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1923.2 | |
| All* | Total formula weight | 99848.1 |
