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4RAB

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DHypoxanthine-guanine phosphoribosyltransferasepolymer21724481.24UniProt (P00492)
Pfam (PF00156)
In PDB
Homo sapiens (human)HGPRT, HGPRTase
2A, B, C, D[(E)-2-(2-{[2-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic acidnon-polymer529.24Chemie (3L3)
3A, B, C, DMAGNESIUM IONnon-polymer24.36Chemie (MG)
4A, B, C, DPHOSPHATE IONnon-polymer95.04Chemie (PO4)
5waterwater18.0152Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight97924.9
Non-Polymers*Number of molecules14
Total formula weight2642.4
All*Total formula weight100567.3
*Water molecules are not included.

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PDB entries from 2024-08-07

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