4RAB
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hypoxanthine-guanine phosphoribosyltransferase | polymer | 217 | 24481.2 | 4 | UniProt (P00492) Pfam (PF00156) | Homo sapiens (human) | HGPRT, HGPRTase |
| 2 | E, H, K, O (A, B, C, D) | [(E)-2-(2-{[2-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic acid | non-polymer | 529.2 | 4 | Chemie (3L3) | |||
| 3 | F, I, L, M, P... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 4 | G, J, N, R (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97924.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2642.4 | |
| All* | Total formula weight | 100567.3 |
