4R8I
High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | C-C motif chemokine 2 | polymer | 77 | 8830.2 | 1 | UniProt (P13500) Pfam (PF00048) | Homo sapiens (human) | HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2 |
| 2 | B (B) | Mirror-Image RNA Oligonucleotide Aptamer NOXE36 | polymer | 40 | 12910.6 | 1 | synthetic construct | ||
| 3 | C (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | D (B) | STRONTIUM ION | non-polymer | 87.6 | 1 | Chemie (SR) | |||
| 5 | E, F, G, H, I (B) | POTASSIUM ION | non-polymer | 39.1 | 5 | Chemie (K) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 1 - 76 (UniProt: P13500)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21740.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 306.1 | |
| All* | Total formula weight | 22047.0 |
