4R6V
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 4 | polymer | 323 | 36173.6 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-4 |
2 | A | N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | non-polymer | 693.6 | 1 | Chemie (FI3) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
PDB | External Database | Details |
---|---|---|
Met 431 | - | expression tag |
Gly 432 | - | expression tag |
Ser 433 | - | expression tag |
Ser 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
Ser 441 | - | expression tag |
Gln 442 | - | expression tag |
Asp 443 | - | expression tag |
Pro 444 | - | expression tag |
Leu 550 | Val 550 | engineered mutation |
Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36173.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 885.7 | |
All* | Total formula weight | 37059.3 |