4R6V

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fibroblast growth factor receptor 4	polymer	323	36173.6	1	UniProt (P22455) Pfam (PF07714)	Homo sapiens (human)	FGFR-4
2	B (A)	N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide	non-polymer		693.6	1	Chemie (FI3)
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E (A)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 445 - 753 (UniProt: P22455)

PDB	External Database	Details
Met 431	-	expression tag
Gly 432	-	expression tag
Ser 433	-	expression tag
Ser 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
Ser 441	-	expression tag
Gln 442	-	expression tag
Asp 443	-	expression tag
Pro 444	-	expression tag
Leu 550	Val 550	engineered mutation
Glu 664	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36173.6
Non-Polymers*	Number of molecules	3
	Total formula weight	885.7
All*	Total formula weight	37059.3

*Water molecules are not included.