4R6U

IL-18 receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, A	Interleukin-18 receptor 1	polymer	317	36645.5	2	UniProt (Q13478) In PDB	Homo sapiens (human)	IL-18R-1, IL-18R1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, IL-1Rrp, IL1R-rp
2	B, D	Interleukin-18	polymer	157	18175.5	2	UniProt (Q14116) Pfam (PF00340) In PDB	Homo sapiens (human)	IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma
3	C, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)

Sequence modifications

C, A: 19 - 329 (UniProt: Q13478)

PDB	External Database	Details
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag

B, D: 1 - 157 (UniProt: Q14116)

PDB	External Database	Details
Ser 38	Cys 74	engineered mutation
Ser 68	Cys 104	engineered mutation
Ser 76	Cys 112	engineered mutation
Ser 127	Cys 163	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109642.0
Non-Polymers*	Number of molecules	8
	Total formula weight	1769.7
All*	Total formula weight	111411.6

*Water molecules are not included.