4R6S
Crystal structure of PPARgammma in complex with SR1663
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31495.6 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (A, B) | 4'-[(2,3-dimethyl-5-{[(1R)-1-(4-nitrophenyl)ethyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid | non-polymer | 547.6 | 2 | Chemie (3K2) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A, B: 203 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Phe 447 | Thr 475 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62991.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1095.2 | |
| All* | Total formula weight | 64086.4 |
