4R5T
Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | M1 family aminopeptidase | polymer | 896 | 104598.6 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum FcB1/Columbia | Pfa-M1 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
5 | A | tert-butyl {(1S)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}carbamate | non-polymer | 332.4 | 1 | Chemie (R5T) | |||
6 | water | water | 18.0 | 479 | Chemie (HOH) |
Sequence modifications
A: 196 - 1084 (UniProt: O96935)
PDB | External Database | Details |
---|---|---|
His 189 | - | expression tag |
His 190 | - | expression tag |
His 191 | - | expression tag |
His 192 | - | expression tag |
His 193 | - | expression tag |
His 194 | - | expression tag |
His 195 | - | expression tag |
Gln 213 | Asn 213 | engineered mutation |
Gln 223 | Asn 223 | engineered mutation |
Pro 378 | His 378 | engineered mutation |
Gln 501 | Asn 501 | engineered mutation |
Gln 745 | Asn 745 | engineered mutation |
Gln 795 | Asn 795 | engineered mutation |
Gln 1069 | Asn 1069 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 104598.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1290.8 | |
All* | Total formula weight | 105889.4 |