4R59
A Carbonic Anhydrase IX Mimic in Complex with a Carbohydrate-Based Sulfamate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29200.9 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | (1R)-1,5-anhydro-1-{[4-(sulfamoyloxy)piperidin-1-yl]sulfonyl}-D-galactitol | non-polymer | 406.4 | 1 | Chemie (3J3) | |||
5 | water | water | 18.0 | 206 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Thr 69 | Glu 69 | engineered mutation |
Leu 91 | Ile 91 | engineered mutation |
Val 130 | Phe 130 | engineered mutation |
Glu 169 | Lys 169 | engineered mutation |
Ala 203 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29200.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 563.9 | |
All* | Total formula weight | 29764.8 |