4R4O
Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Replication protein A 70 kDa DNA-binding subunit | polymer | 123 | 13497.7 | 1 | UniProt (P27694) Pfam (PF04057) In PDB | Homo sapiens (human) | RP-A p70, Replication factor A protein 1, RF-A protein 1, Single-stranded DNA-binding protein, Replication protein A 70 kDa DNA-binding subunit, N-terminally processed |
2 | A | 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]carbamothioyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid | non-polymer | 592.4 | 1 | Chemie (3HW) | |||
3 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 1 - 120 (UniProt: P27694)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Arg 7 | Glu 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 13497.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 592.4 | |
All* | Total formula weight | 14090.2 |