4R1Y
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 292 | 33048.4 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | B (A) | 3-(diethylamino)propyl (3-{[5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3(6H)-yl]methyl}phenyl)carbamate | non-polymer | 514.6 | 1 | Chemie (3EH) | |||
| 3 | C, D (A) | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | non-polymer | 310.4 | 2 | Chemie (7PE) | |||
| 4 | E (A) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33048.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1135.4 | |
| All* | Total formula weight | 34183.8 |
