4R07
Crystal structure of human TLR8 in complex with ORN06
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Toll-like receptor 8 | polymer | 811 | 92835.4 | 4 | UniProt (Q9NR97) Pfam (PF13855) | Homo sapiens (human) | |
| 2 | E (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 3 | F, H, I, L, M... (F, H, I, L, M...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
| 4 | G, J, P (G, J, P) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K (K) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | EA, KA, Q, X (C, D, A, B) | URIDINE | non-polymer | 244.2 | 4 | Chemie (URI) | |||
| 7 | FA, LA, R, Y (C, D, A, B) | 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate) | non-polymer | 731.4 | 4 | Chemie (UCG) | |||
| 8 | AA, BA, CA, DA, GA... (B, C, D, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
| 9 | QA, RA, SA, TA (A, B, C, D) | water | water | 18.0 | 1434 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 26 - 827 (UniProt: Q9NR97)
| PDB | External Database | Details |
|---|---|---|
| Arg 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Trp 25 | - | expression tag |
| Glu 828 | - | expression tag |
| Phe 829 | - | expression tag |
| Leu 830 | - | expression tag |
| Val 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 371341.5 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 6876.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 7884.0 | |
| All* | Total formula weight | 386101.8 |
