4R07
Crystal structure of human TLR8 in complex with ORN06
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Toll-like receptor 8 | polymer | 811 | 92835.4 | 4 | UniProt (Q9NR97) Pfam (PF13855) In PDB | Homo sapiens (human) | |
2 | E | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
3 | F, H, I, L, M... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
4 | G, J, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
5 | K | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
6 | C, D, A, B | URIDINE | non-polymer | 244.2 | 4 | Chemie (URI) | |||
7 | C, D, A, B | 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate) | non-polymer | 731.4 | 4 | Chemie (UCG) | |||
8 | B, C, D, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
9 | water | water | 18.0 | 1434 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 26 - 827 (UniProt: Q9NR97)
PDB | External Database | Details |
---|---|---|
Arg 22 | - | expression tag |
Ser 23 | - | expression tag |
Pro 24 | - | expression tag |
Trp 25 | - | expression tag |
Glu 828 | - | expression tag |
Phe 829 | - | expression tag |
Leu 830 | - | expression tag |
Val 831 | - | expression tag |
Pro 832 | - | expression tag |
Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 371341.5 | |
Branched | Number of molecules | 12 |
Total formula weight | 6876.4 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 7884.0 | |
All* | Total formula weight | 386101.8 |