4QZV

Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Dipeptidyl peptidase 4	polymer	734	85291.5	2	UniProt (P27487) Pfam (PF00930) Pfam (PF00326)	Homo sapiens (human)	ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form
2	B, D (B, D)	Spike protein S1	polymer	246	27023.5	2	UniProt (A3EX94) Pfam (PF09408)	Tylonycteris bat coronavirus HKU4 (BtCoV)
3	E, G, H, I, K... (E, G, H, I, K...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
4	F, J (F, J)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	M, N, O, P, Q (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	R, S, T, U (A, B, C, D)	water	water		18.0	476	Chemie (HOH)

Sequence modifications

A, C: 39 - 766 (UniProt: P27487)

PDB	External Database	Details
His 767	-	expression tag
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag

B, D: 1 - 240 (UniProt: A3EX94)

PDB	External Database	Details
His 241	-	expression tag
His 242	-	expression tag
His 243	-	expression tag
His 244	-	expression tag
His 245	-	expression tag
His 246	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	224630.0
Branched	Number of molecules	8
	Total formula weight	3719.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	229455.6

*Water molecules are not included.