4QYF

CHK1 kinase domain in complex with aminopyrazine compound 13

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase Chk1	polymer	298	34205.2	1	UniProt (O14757) Pfam (PF00069) In PDB	Homo sapiens (human)	CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1
2	A	4-[3-amino-6-(3-hydroxyphenyl)pyrazin-2-yl]benzoic acid	non-polymer		307.3	1	Chemie (3DV)
3		water	water		18.0	194	Chemie (HOH)

Sequence modifications

A: 1 - 289 (UniProt: O14757)

PDB	External Database	Details
Gly 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34205.2
Non-Polymers*	Number of molecules	1
	Total formula weight	307.3
All*	Total formula weight	34512.5

*Water molecules are not included.