4QX4
Human Aldose Reductase complexed with a ligand with a new scaffold at 1.26 A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldose reductase | polymer | 316 | 35898.3 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (human) | AR, Aldehyde reductase, Aldo-keto reductase family 1 member B1 |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (4412) PubChem (46936685) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (5885) PubChem (165382010) | |||
| 3 | C, D (A) | (3-thioxo-2,3-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid | non-polymer | 260.3 | 2 | Chemie (3E2) PubChem (685919) | |||
| 4 | E (A) | water | water | 18.0 | 334 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Ile 4 | Leu 5 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35898.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1263.9 | |
| All* | Total formula weight | 37162.3 |
