4QWG
yCP beta5-A49V mutant in complex with carfilzomib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome subunit alpha type-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT Y7, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y7, PROTEASOME COMPONENT Y7, PROTEINASE YSCE SUBUNIT 7 |
| 2 | B, P (B, P) | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT Y13, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y13, PROTEASOME COMPONENT Y13, PROTEINASE YSCE SUBUNIT 13 |
| 3 | C, Q (C, Q) | Proteasome subunit alpha type-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PRE6, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE6, PROTEASOME COMPONENT PRE6, PROTEINASE YSCE SUBUNIT PRE6 |
| 4 | D, R (D, R) | Proteasome subunit alpha type-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PUP2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP2, PROTEASOME COMPONENT PUP2, PROTEINASE YSCE SUBUNIT PUP2 |
| 5 | E, S (E, S) | Proteasome subunit alpha type-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF00227) Pfam (PF10584) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PRE5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE5, PROTEASOME COMPONENT PRE5, PROTEINASE YSCE SUBUNIT PRE5 |
| 6 | F, T (F, T) | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT C1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C1, PROTEASOME COMPONENT C1, PROTEINASE YSCE SUBUNIT 1 |
| 7 | G, U (G, U) | Proteasome subunit alpha type-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT C7-ALPHA, MULTICATALYTIC ENDOPEPTIDASE COMPLEX C7, PROTEASOME COMPONENT C7-ALPHA, PROTEASOME COMPONENT Y8, PROTEINASE YSCE SUBUNIT 7, SCL1 SUPPRESSOR PROTEIN |
| 8 | H, V (H, V) | Proteasome subunit beta type-2 | polymer | 232 | 25114.5 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PUP1, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1, PROTEASOME COMPONENT PUP1, PROTEINASE YSCE SUBUNIT PUP1 |
| 9 | I, W (I, W) | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PUP3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP3, PROTEASOME COMPONENT PUP3 |
| 10 | J, X (J, X) | Proteasome subunit beta type-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT C11, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C11, PROTEASOME COMPONENT C11, PROTEINASE YSCE SUBUNIT 11 |
| 11 | K, Y (K, Y) | Proteasome subunit beta type-5 | polymer | 212 | 23353.3 | 2 | UniProt (P30656) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PRE2, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2, PROTEASOME COMPONENT PRE2, PROTEINASE YSCE SUBUNIT PRE2 |
| 12 | L, Z (L, Z) | Proteasome subunit beta type-6 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C5, PROTEASOME COMPONENT C5 |
| 13 | AA, M (M, a) | Proteasome subunit beta type-7 | polymer | 246 | 27200.9 | 2 | UniProt (P30657) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PRE4, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE4, PROTEASOME COMPONENT PRE4, PROTEINASE YSCE SUBUNIT PRE4 |
| 14 | BA, N (N, b) | Proteasome subunit beta type-1 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) | Saccharomyces cerevisiae (Baker's yeast) | MACROPAIN SUBUNIT PRE3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3, PROTEASOME COMPONENT PRE3, PROTEINASE YSCE SUBUNIT PRE3 |
| 15 | CA, FA, HA, KA, OA... (G, I, K, N, V...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 16 | DA, LA, MA, TA (G, N, U, b) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 17 | EA, GA, JA, NA, PA... (H, K, N, V, Y...) | N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide | non-polymer | 723.9 | 6 | BIRD (PRD_001243) Chemie (3BV) | |||
| 18 | IA, RA (K, Y) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 19 | AB, BB, CB, DB, EB... (G, H, I, J, K...) | water | water | 18.0 | 704 | Chemie (HOH) |
Sequence modifications
K, Y: 1 - 212 (UniProt: P30656)
| PDB | External Database | Details |
|---|---|---|
| Val 49 | Ala 124 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 731106.9 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5021.8 | |
| All* | Total formula weight | 736128.6 |
