4QW5
yCP beta5-M45A mutant in complex with carfilzomib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O | Proteasome subunit alpha type-2 | polymer | 250 | 27191.8 | 2 | UniProt (P23639) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 2 | B, P | Proteasome subunit alpha type-3 | polymer | 258 | 28748.2 | 2 | UniProt (P23638) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 3 | C, Q | Proteasome subunit alpha type-4 | polymer | 254 | 28478.1 | 2 | UniProt (P40303) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 4 | D, R | Proteasome subunit alpha type-5 | polymer | 260 | 28649.1 | 2 | UniProt (P32379) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 5 | E, S | Proteasome subunit alpha type-6 | polymer | 234 | 25634.0 | 2 | UniProt (P40302) Pfam (PF00227) Pfam (PF10584) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 6 | F, T | Probable proteasome subunit alpha type-7 | polymer | 288 | 31575.1 | 2 | UniProt (P21242) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 7 | G, U | Proteasome subunit alpha type-1 | polymer | 252 | 28033.8 | 2 | UniProt (P21243) Pfam (PF10584) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 8 | H, V | Proteasome subunit beta type-2 | polymer | 232 | 25114.5 | 2 | UniProt (P25043) Pfam (PF00227) Pfam (PF12465) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 9 | I, W | Proteasome subunit beta type-3 | polymer | 205 | 22627.8 | 2 | UniProt (P25451) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 10 | J, X | Proteasome subunit beta type-4 | polymer | 198 | 22545.7 | 2 | UniProt (P22141) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 11 | K, Y | Proteasome subunit beta type-5 | polymer | 212 | 23265.1 | 2 | UniProt (P30656) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 12 | L, Z | Proteasome subunit beta type-6 | polymer | 222 | 24883.9 | 2 | UniProt (P23724) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 13 | M, a | Proteasome subunit beta type-7 | polymer | 246 | 27200.9 | 2 | UniProt (P30657) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 14 | N, b | Proteasome subunit beta type-1 | polymer | 196 | 21517.2 | 2 | UniProt (P38624) Pfam (PF00227) In PDB | Saccharomyces cerevisiae (Baker's yeast) | |
| 15 | G, K, N, Y, Z | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 16 | G, N, U, b | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 17 | H, K, N, V, Y... | N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide | non-polymer | 723.9 | 6 | BIRD (PRD_001243) Chemie (3BV) | |||
| 18 | H, K, V, Y | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) | |||
| 19 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
K, Y: 1 - 212 (UniProt: P30656)
| PDB | External Database | Details |
|---|---|---|
| Ala 45 | Met 120 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 730930.5 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 5387.9 | |
| All* | Total formula weight | 736318.5 |
