4QQC
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 4 | polymer | 323 | 36159.6 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-4 |
2 | A | N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide | non-polymer | 636.7 | 1 | Chemie (37O) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
PDB | External Database | Details |
---|---|---|
Met 431 | - | expression tag |
Gly 432 | - | expression tag |
Ser 433 | - | expression tag |
Ser 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
Ser 441 | - | expression tag |
Gln 442 | - | expression tag |
Asp 443 | - | expression tag |
Pro 444 | - | expression tag |
Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36159.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 732.8 | |
All* | Total formula weight | 36892.4 |