4QQC

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fibroblast growth factor receptor 4	polymer	323	36159.6	1	UniProt (P22455) Pfam (PF07714)	Homo sapiens (human)	FGFR-4
2	B (A)	N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide	non-polymer		636.7	1	Chemie (37O)
3	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	D (A)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A: 445 - 753 (UniProt: P22455)

PDB	External Database	Details
Met 431	-	expression tag
Gly 432	-	expression tag
Ser 433	-	expression tag
Ser 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
Ser 441	-	expression tag
Gln 442	-	expression tag
Asp 443	-	expression tag
Pro 444	-	expression tag
Glu 664	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36159.6
Non-Polymers*	Number of molecules	2
	Total formula weight	732.8
All*	Total formula weight	36892.4

*Water molecules are not included.