4QQ5

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 4	polymer	323	36173.6	1	UniProt (P22455) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-4
2	A	N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide	non-polymer		636.7	1	Chemie (37O)

Sequence modifications

A: 450 - 758 (UniProt: P22455)

PDB	External Database	Details
Met 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag
Ser 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
Ser 446	-	expression tag
Gln 447	-	expression tag
Asp 448	-	expression tag
Pro 449	-	expression tag
Leu 555	Val 550	engineered mutation
Glu 669	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36173.6
Non-Polymers*	Number of molecules	1
	Total formula weight	636.7
All*	Total formula weight	36810.3

*Water molecules are not included.