4QPS
Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Tyrosine-protein kinase JAK3 | polymer | 293 | 33302.1 | 2 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| 2 | C, D (A, C) | N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide | non-polymer | 356.4 | 2 | Chemie (37Q) | |||
| 3 | E, F (A, C) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A, C: 811 - 1103 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ala 949 | Asp 949 | engineered mutation |
| Ser 1040 | Cys 1040 | engineered mutation |
| Ser 1048 | Cys 1048 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66604.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 712.8 | |
| All* | Total formula weight | 67317.1 |
