4QPP

The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Protein arginine N-methyltransferase 6	polymer	376	42074.6	3	UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528)	Homo sapiens (human)	Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6
2	D, E, F (D, E, F)	POLY-UNK	polymer	7	613.7	3		Homo sapiens (human)
3	G, I, K (A, B, C)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	3	Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
4	H, J, L (A, B, C)	2-{4-[3-chloro-2-(2-methoxyphenyl)-1H-indol-5-yl]piperidin-1-yl}-N-methylethanamine	non-polymer		397.9	3	Chemie (36S)
5	M, N, O (A, B, C)	water	water		18.0	282	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 375 (UniProt: Q96LA8)

PDB	External Database	Details
Gly 0	-	expression tag
Val 194	Ala 194	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	128064.9
Non-Polymers*	Number of molecules	6
	Total formula weight	2347.1
All*	Total formula weight	130412.0

*Water molecules are not included.