4QPP
The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Protein arginine N-methyltransferase 6 | polymer | 376 | 42074.6 | 3 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) In PDB | Homo sapiens (human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6 |
| 2 | D, E, F | POLY-UNK | polymer | 7 | 613.7 | 3 | Homo sapiens (human) | ||
| 3 | A, B, C | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 3 | Chemie (SAH) | |||
| 4 | A, B, C | 2-{4-[3-chloro-2-(2-methoxyphenyl)-1H-indol-5-yl]piperidin-1-yl}-N-methylethanamine | non-polymer | 397.9 | 3 | Chemie (36S) | |||
| 5 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 194 | Ala 194 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 128064.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2347.1 | |
| All* | Total formula weight | 130412.0 |
