4QPA

Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mitogen-activated protein kinase 1	polymer	369	42627.8	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	C, D (A, B)	7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine	non-polymer		352.4	2	Chemie (35W)

Sequence modifications

A, B: -1 - 358 (UniProt: P28482)

PDB	External Database	Details
Met -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85255.7
Non-Polymers*	Number of molecules	2
	Total formula weight	704.8
All*	Total formula weight	85960.4

*Water molecules are not included.