4QP6
Crystal Structure of ERK2 in complex with 5H-pyrrolo[2,3-b]pyrazine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Mitogen-activated protein kinase 1 | polymer | 369 | 42627.8 | 2 | UniProt (P28482) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2 |
2 | A, B | 5H-pyrrolo[2,3-b]pyrazine | non-polymer | 119.1 | 2 | Chemie (36N) | |||
3 | A | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) |
Sequence modifications
A, B: 1 - 360 (UniProt: P28482)
PDB | External Database | Details |
---|---|---|
Met -8 | - | EXPRESSION TAG |
Gly -7 | - | EXPRESSION TAG |
Ser -6 | - | EXPRESSION TAG |
His -5 | - | EXPRESSION TAG |
His -4 | - | EXPRESSION TAG |
His -3 | - | EXPRESSION TAG |
His -2 | - | EXPRESSION TAG |
His -1 | - | EXPRESSION TAG |
His 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85255.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 307.3 | |
All* | Total formula weight | 85563.0 |