4QP3

Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mitogen-activated protein kinase 1	polymer	369	42627.8	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	C, D (A, B)	(2S)-3-phenyl-2-(9H-purin-6-ylamino)propan-1-ol	non-polymer		269.3	2	Chemie (36Q)
3	E, F (A, B)	water	water		18.0	162	Chemie (HOH)

Sequence modifications

A, B: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Met -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85255.7
Non-Polymers*	Number of molecules	2
	Total formula weight	538.6
All*	Total formula weight	85794.3

*Water molecules are not included.