4QNZ
Crystal structure of rhomboid intramembrane protease GlpG F146I in complex with peptide derived inhibitor Ac-FATA-cmk
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Rhomboid protease GlpG | polymer | 200 | 22703.9 | 1 | UniProt (U6NA71) | Escherichia coli | Intramembrane serine protease |
| 2 | B (B) | ACE-PHE-ALA-THR-ALA-0QE | polymer | 6 | 467.0 | 1 | BIRD (PRD_001251) | ||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 4 | D (A) | nonyl beta-D-glucopyranoside | non-polymer | 306.4 | 1 | Chemie (BNG) PubChem (57484544) PubChem (67410050) PubChem (67410054) PubChem (67410579) PubChem (67410580) PubChem (67410693) PubChem (67411265) PubChem (67411760) PubChem (67412070) PubChem (67412159) PubChem (67412975) PubChem (67413017) PubChem (71245600) PubChem (92471074) PubChem (92471075) PubChem (94290254) PubChem (94290256) PubChem (95566082) PubChem (95566083) PubChem (101527253) PubChem (113558) PubChem (155448) PubChem (9818005) PubChem (11415532) PubChem (129854788) PubChem (12986435) PubChem (131676744) PubChem (14656373) PubChem (136212546) | |||
| 5 | E (A) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 87 - 276 (UniProt: U6NA71)
| PDB | External Database | Details |
|---|---|---|
| Ile 146 | Phe 146 | engineered mutation |
| Ala 277 | - | expression tag |
| Ser 278 | - | expression tag |
| Leu 279 | - | expression tag |
| Glu 280 | - | expression tag |
| Arg 281 | - | expression tag |
| Glu 282 | - | expression tag |
| Asn 283 | - | expression tag |
| Leu 284 | - | expression tag |
| Tyr 285 | - | expression tag |
| Phe 286 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23170.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 341.8 | |
| All* | Total formula weight | 23512.7 |
