4QMN

MST3 in complex with BOSUTINIB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein kinase 24	polymer	310	35023.9	1	UniProt (Q9Y6E0) Pfam (PF00069)	Homo sapiens (human)	Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3, Serine/threonine-protein kinase 24 36 kDa subunit, Mammalian STE20-like protein kinase 3 N-terminal, MST3/N, Serine/threonine-protein kinase 24 12 kDa subunit, Mammalian STE20-like protein kinase 3 C-terminal, MST3/C
2	B (A)	4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile	non-polymer		530.4	1	Chemie (DB8)
3	C (A)	water	water		18.0	134	Chemie (HOH)

Sequence modifications

A: 15 - 303 (UniProt: Q9Y6E0)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
Leu -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Met 1	-	expression tag
Ala 2	-	expression tag
His 3	-	expression tag
Ser 4	-	expression tag
Pro 5	-	expression tag
Val 6	-	expression tag
Gln 7	-	expression tag
Ser 8	-	expression tag
Gly 9	-	expression tag
Leu 10	-	expression tag
Pro 11	-	expression tag
Gly 12	-	expression tag
Met 13	-	expression tag
Gln 14	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35023.9
Non-Polymers*	Number of molecules	1
	Total formula weight	530.4
All*	Total formula weight	35554.4

*Water molecules are not included.