4QM0
Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Nuclear receptor ROR-gamma | polymer | 251 | 29041.5 | 2 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR-related orphan receptor C, Retinoid-related orphan receptor-gamma |
| 2 | C, E (A, C) | N-(2-methylpropyl)-N-({5-[4-(methylsulfonyl)phenyl]thiophen-2-yl}methyl)-1-phenylmethanesulfonamide | non-polymer | 477.7 | 2 | Chemie (39K) | |||
| 3 | D, F (A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A, C: 262 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 260 | - | expression tag |
| Ser 261 | - | expression tag |
| Gly 508 | - | expression tag |
| Asn 509 | - | expression tag |
| Ser 510 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58083.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1111.6 | |
| All* | Total formula weight | 59194.7 |
