4QL1
Crystal structure of human WDR5 in complex with compound OICR-9429
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | WD repeat-containing protein 5 | polymer | 312 | 34289.9 | 2 | UniProt (P61964) Pfam (PF00400) In PDB | Homo sapiens (human) | BMP2-induced 3-kb gene protein |
| 2 | A, B | N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide | non-polymer | 555.6 | 2 | Chemie (35Q) | |||
| 3 | A, B | UNKNOWN ATOM OR ION | non-polymer | 2 | Chemie (UNX) | ||||
| 4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68579.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1265.3 | |
| All* | Total formula weight | 69845.1 |
