4QJ9
Crystal structure of inactive HIV-1 protease in complex with p1-p6 substrate variant (R452S)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10842.9 | 2 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) (HIV-1) | Retropepsin |
| 2 | C (G) | p1-p6 peptide | polymer | 10 | 1103.2 | 1 | UniProt (by SIFTS) (P03349) | Human immunodeficiency virus type 1 (ARV2/SF2 ISOLATE) | |
| 3 | D, E, F, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 4 | G, H, I, K, L (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | M, N, O (A, B, G) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Asn 25 | Asp 515 | engineered mutation |
| Ile 64 | Val 554 | engineered mutation |
| Val 71 | Ala 561 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22788.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 840.4 | |
| All* | Total formula weight | 23629.3 |
