4QGW
Crystal structure of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular retinoic acid-binding protein 2 | polymer | 137 | 15511.7 | 2 | UniProt (P29373) Pfam (PF00061) | Homo sapiens (human) | Cellular retinoic acid-binding protein II, CRABP-II |
| 2 | C (A) | (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal | non-polymer | 267.4 | 1 | Chemie (LMC) | |||
| 3 | D (A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 137 (UniProt: P29373)
| PDB | External Database | Details |
|---|---|---|
| Leu 111 | Arg 112 | engineered mutation |
| Asp 121 | Leu 122 | engineered mutation |
| Lys 132 | Arg 133 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31023.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 549.7 | |
| All* | Total formula weight | 31573.1 |
