4QG8
crystal structure of PKM2-K305Q mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKM | polymer | 535 | 58314.1 | 4 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58 |
| 2 | E, I, L (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | F, J, M (A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, K, N (A, B, C) | MALONATE ION | non-polymer | 102.0 | 3 | Chemie (MLI) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 657 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 305 | Lys 305 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 233256.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 588.4 | |
| All* | Total formula weight | 233844.8 |
