4QG4
Crystal structure of the tetrameric GTP/dATP/ATP-bound SAMHD1 (H210A) mutant catalytic core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 550 | 63341.3 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) In PDB | Homo sapiens (human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
| 2 | A, B | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
| 3 | A, B, C, D | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 4 | Chemie (DTP) | |||
| 4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 569 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | expression tag |
| Gly 78 | - | expression tag |
| Ser 79 | - | expression tag |
| Ser 80 | - | expression tag |
| His 81 | - | expression tag |
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| His 84 | - | expression tag |
| His 85 | - | expression tag |
| His 86 | - | expression tag |
| Ser 87 | - | expression tag |
| Ser 88 | - | expression tag |
| Gly 89 | - | expression tag |
| Leu 90 | - | expression tag |
| Val 91 | - | expression tag |
| Pro 92 | - | expression tag |
| Arg 93 | - | expression tag |
| Gly 94 | - | expression tag |
| Ser 95 | - | expression tag |
| His 96 | - | expression tag |
| Met 97 | - | expression tag |
| Ala 98 | - | expression tag |
| Ser 99 | - | expression tag |
| Met 100 | - | expression tag |
| Thr 101 | - | expression tag |
| Gly 102 | - | expression tag |
| Gly 103 | - | expression tag |
| Gln 104 | - | expression tag |
| Gln 105 | - | expression tag |
| Met 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Arg 108 | - | expression tag |
| Asp 109 | - | expression tag |
| Pro 110 | - | expression tag |
| Asn 111 | - | expression tag |
| Ser 112 | - | expression tag |
| Ala 210 | His 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 253365.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4416.3 | |
| All* | Total formula weight | 257781.3 |
