4QC4

Crystal structure of C117S mutant of human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor 1	polymer	146	16670.7	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (human)	FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1
2	C, G (A, B)	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
3	D (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	E, F (A)	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
5	H, I (A, B)	water	water		18.0	428	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ser 117	Cys 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33341.4
Non-Polymers*	Number of molecules	5
	Total formula weight	539.4
All*	Total formula weight	33880.7

*Water molecules are not included.