4QA2

Crystal structure of I243N HDAC8 in complex with SAHA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone deacetylase 8	polymer	389	43232.9	2	UniProt (Q9BY41) Pfam (PF00850)	Homo sapiens (human)	HD8
2	C, D, G, H (A, B)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
3	E, I (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	F, J (A, B)	OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE	non-polymer		264.3	2	Chemie (SHH)
5	K, L (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	M, N (A, B)	water	water		18.0	180	Chemie (HOH)

Sequence modifications

A, B: 1 - 377 (UniProt: Q9BY41)

PDB	External Database	Details
Asn 243	Ile 243	engineered mutation
Ile 378	-	expression tag
Glu 379	-	expression tag
Gly 380	-	expression tag
Arg 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86465.9
Non-Polymers*	Number of molecules	10
	Total formula weight	1000.0
All*	Total formula weight	87465.9

*Water molecules are not included.