4Q91

Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor 1	polymer	146	16622.6	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (human)	FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1
2	C, D, F, G, H (A, B)	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT)
3	E (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	I, J (A, B)	water	water		18.0	344	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Val 12	Lys 27	engineered mutation
Ala 16	Cys 31	engineered mutation
Val 117	Cys 132	engineered mutation
Val 134	Pro 149	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33245.3
Non-Polymers*	Number of molecules	6
	Total formula weight	325.1
All*	Total formula weight	33570.4

*Water molecules are not included.