4Q7H

Crystal structure of SAMHD1 catalytic core with GTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	526	61097.7	4	UniProt (Q9Y3Z3) Pfam (PF01966)	Homo sapiens (human)	dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1
2	E, G, I, K (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	F, H, J (A, B, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	3	Chemie (GTP)
4	L, M, N, O (A, B, C, D)	water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, B, C, D: 109 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
His 101	-	expression tag
His 102	-	expression tag
His 103	-	expression tag
His 104	-	expression tag
His 105	-	expression tag
His 106	-	expression tag
Gly 107	-	expression tag
Ser 108	-	expression tag
Tyr 266	Cys 266	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	244390.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1831.2
All*	Total formula weight	246222.0

*Water molecules are not included.