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4Q1X

Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BASPARTYL PROTEASEpolymer9910829.82UniProt (V5Y949)
Pfam (PF00077)
UniProt (by SIFTS) (P04585)
In PDB
Human immunodeficiency virus 1
2A(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATEnon-polymer547.71Chemie (017)
3AGLYCEROLnon-polymer92.11Chemie (GOL)
4BPHOSPHATE IONnon-polymer95.01Chemie (PO4)
5waterwater18.093Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: V5Y949)
PDBExternal DatabaseDetails
Lys 7Gln 7engineered mutation
Ile 32Val 32engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight21659.6
Non-Polymers*Number of molecules3
Total formula weight734.7
All*Total formula weight22394.4
*Water molecules are not included.

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PDB entries from 2024-07-31

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