4Q0B
Crystal structure of HIV-1 reverse transcriptase in complex with gap-RNA/DNA and Nevirapine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | HIV-1 reverse transcriptase, p66 subunit | polymer | 556 | 64022.4 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 (HIV-1) | |
2 | B, D | HIV-1 reverse transcriptase, p51 subunit | polymer | 428 | 50039.5 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 (HIV-1) | |
3 | T, E | 5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*G)-3' | polymer | 14 | 4493.7 | 2 | |||
4 | t, e | 5'-R(P*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3' | polymer | 12 | 3891.4 | 2 | |||
5 | P, F | 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3' | polymer | 21 | 6416.1 | 2 | |||
6 | A, C | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE | non-polymer | 266.3 | 2 | Chemie (NVP) | |||
7 | A, C | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
8 | e | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
A, C: 1 - 554 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Val 0 | - | expression tag |
Cys 258 | Gln 857 | engineered mutation |
Ser 280 | Cys 879 | engineered mutation |
Asn 498 | Asp 1097 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 257726.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 738.5 | |
All* | Total formula weight | 258464.8 |