4Q02
Second-site screening of K-Ras in the presence of covalently attached first-site ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase KRas | polymer | 170 | 19370.9 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | 3,4-difluorobenzenethiol | non-polymer | 146.2 | 1 | Chemie (2XG) PubChem (2778378) | |||
| 5 | E (A) | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 12 | Gly 12 | engineered mutation |
| Cys 39 | Ser 39 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19370.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 613.7 | |
| All* | Total formula weight | 19984.6 |
